Transdermal progesterone creams for postmenopausal women: more hype than hope?
نویسنده
چکیده
Various claims have been made about the benefits of transdermal progesterone creams for relieving symptoms of menopause. Peer-reviewed articles have reported that the creams can raise plasma progesterone levels slightly, but have no effect on vasomotor, psychosexual or mood symptoms, bone metabolism or plasma lipid levels. Currently available progesterone creams can not be recommended for treatment of symptoms associated with menopause.
منابع مشابه
Caution on the use of saliva measurements to monitor absorption of progesterone from transdermal creams in postmenopausal women.
OBJECTIVES To determine the levels of progesterone in plasma, red cells and saliva as well as pregnanediol-3-glucuronide excretion in postmenopausal women using transdermal progesterone creams. METHODS A double-blind placebo controlled study was carried out using 24 postmenopausal women. Creams (placebo, 20 or 40 mg progesterone/g) were applied twice daily for 3 weeks followed by 1 week witho...
متن کاملActivated protein C resistance among postmenopausal women using transdermal estrogens: importance of progestogen.
OBJECTIVE Although the route of estrogen administration is known to be an important determinant of the thrombotic risk among postmenopausal women using hormone therapy, recent data have shown that norpregnane derivatives but not micronized progesterone increase venous thromboembolism risk among transdermal estrogens users. However, the differential effects of progesterone and norpregnanes on he...
متن کاملEffects of Hormone Therapy on Serum Lipid Levels in Postmenopausal Korean Women
OBJECTIVES This study was conducted to examine the effects of hormone therapy on serum lipid levels in postmenopausal Korean women. METHODS This retrospective cohort study included 154 healthy postmenopausal Korean women. Seventy-nine women took oral estrogen (conjugated equine estrogen 0.625 mg/day or equivalent), and 75 applied estrogen transdermally using 0.1% 17β-estradiol gel. Micronized...
متن کاملThe effects of transdermal estrogen delivery on bone mineral density in postmenopausal women: A meta-analysis
Background: Due to its minimal systematic adverse effects, transdermal estrogen is widely used for the prevention of osteoporosis in postmenopausal women.The present meta-analysis aimed to clarify the effects of transdermal estrogen on bone mineral density (BMD) of postmenopausal women.Methods: Studies were identified by searching electronic databases including Cochrane Library, MEDLINE, Embase...
متن کاملEffect of sequential transdermal progesterone cream on endometrium, bleeding pattern, and plasma progesterone and salivary progesterone levels in postmenopausal women.
BACKGROUND Transdermal progesterone is being used in some countries as a purported treatment for menopausal symptoms, either alone or prescribed in conjunction with estrogen, but little information exists regarding the biological activity and effectiveness of this method of delivery of progesterone in protecting the endometrium from excess proliferation. This study was designed to evaluate the ...
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ورودعنوان ژورنال:
- The Medical journal of Australia
دوره 182 5 شماره
صفحات -
تاریخ انتشار 2005